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Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States

https://doi.org/10.3201/eid2703.191775

Randad, Pranay R. ; Larsen, Jesper ; Kaya, Hülya ; Pisanic, Nora ; Ordak, Carly ; Price, Lance B. ; Aziz, Maliha ; Nadimpalli, Maya L. ; Rhodes, Sarah ; Stewart, Jill R. ; et al ( March 2021 , Emerging Infectious Diseases)

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Comparison of livestock-associated and community-associated Staphylococcus aureus pathogenicity in a mouse model of skin and soft tissue infection

https://doi.org/10.1038/s41598-019-42919-y

Randad, Pranay R. ; Dillen, Carly A. ; Ortines, Roger V. ; Mohr, David ; Aziz, Maliha ; Price, Lance B. ; Kaya, Hülya ; Larsen, Jesper ; Carroll, Karen C. ; Smith, Tara C. ; et al ( May 2019 , Scientific Reports)

Abstract
Industrial hog operation (IHO) workers are at increased risk of carryingStaphylococcus aureusin their nares, particularly strains that are livestock-associated (LA) and multidrug-resistant. The pathogenicity of LA-S. aureusstrains remains unclear, with some prior studies suggesting reduced transmission and virulence in humans compared to community-associated methicillin-resistant (CA-MRSA)S. aureus. The objective of this study was to determine the degree to which LA-S. aureusstrains contracted by IHO workers cause disease relative to a representative CA-MRSA strain in a mouse model of skin and soft tissue infection (SSTI). Mice infected with CC398 LA-S. aureusstrains (IHW398-1 and IHW398-2) developed larger lesion sizes with higher bacterial burden than mice infected with CA-MRSA (SF8300) (p < 0.05). The greatest lesion size and bacterial burden was seen with a CC398 strain that produced a recurrent SSTI in an IHO worker. The LA-S. aureusinfected mice had decreased IL-1β protein levels compared with CA-MRSA-infected mice (p < 0.05), suggesting a suboptimal host response to LA-S. aureusSSTIs. WGSA revealed heterogeneity in virulence factor and antimicrobial resistance genes carried by LA-S. aureusand CA-MRSA strains. The observed pathogenicity suggest that more attention should be placed on preventing the spread of LA-S. aureusinto human populations.

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